Hydrogen exhibits selective antioxidant properties, neutralizing harmful free radicals (such as hydroxyl radicals and peroxynitrite) while sparing beneficial reactive oxygen species. This ability helps alleviate oxidative stress and reduce inflammatory responses. Studies show that hydrogen inhibits pro-inflammatory signaling pathways like NF-κB, decreasing the release of inflammatory cytokines. Its small molecular size allows rapid diffusion into cells and mitochondria, directly protecting them from oxidative damage.

1. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

https://pubmed.ncbi.nlm.nih.gov/23031079/

2. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

https://pubmed.ncbi.nlm.nih.gov/34987419/

3. Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

https://pubmed.ncbi.nlm.nih.gov/30243702/

4. Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response

https://pubmed.ncbi.nlm.nih.gov/32361189/

5. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease

https://pubmed.ncbi.nlm.nih.gov/21238541/

6. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

https://pubmed.ncbi.nlm.nih.gov/21621588/

7. Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

https://pubmed.ncbi.nlm.nih.gov/34784538/

8. A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

https://pubmed.ncbi.nlm.nih.gov/31159153/

9. Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress

https://pubmed.ncbi.nlm.nih.gov/33806292/

10. Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice

https://pubmed.ncbi.nlm.nih.gov/29568538/